School of Mathematics

Search site

Prof Jeanine J Houwing-Duistermaat

Professor in Data Analytics

Contact details

Room: Satellite 10.13
Tel: +44 (0)113 3439821
Email: J.Duistermaat @


Family data
NGS and Omics data
Data from electronic patient records
Random effects models
Outcome dependent sampling
Survival analysis

Research interests

My work is motivated by ongoing collaborations with clinicians, biologists, psychologists and chemists. Random effects models is the research theme which is the basis of my work especially in family data. Within the EU funded FP7 Consortium MIMOmics, which I coordinate, methods for integrated analysis of multiple omics data are being developed. Finally using data from electronic patient records for risk prediction and study design is a new and interesting research topic in statistics.

Useful links

My personal website
My publications in google scholar

Current postgraduate students

Emeka Uzochukwu (2017)


Bartzis G, Deelen J, Maia J, Ligterink W, Hilhorst HWM, Houwing-Duistermaat JJ, van Eeuwijk F, Uh HW Estimation of metabolite networks with regard to a specific covariable: applications to plant and human data Metabolomics, 13, 2017
View abstract

Houwing-Duistermaat JJ, Uh HW, Gusnanto A Discussion on the paper‘Statistical contributions to bioinformatics: Design, modelling, structure learning and integration’ by Jeffrey S. Morris and Veerabhadran Baladandayuthapani Statistical Modelling, 17, 319-326, 2017
View abstract

Tissier R, Tsonaka R, Mooijaart SP, Slagboom E, Houwing-Duistermaat JJ Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study Statistics in Medicine, 36, 2288-2301, 2017
View abstract

de Ruiter K, Tahapary DL, Wammes LJ, Wiria AE, Hamid F, van Lieshout L, Smit JWA, Houwing-Duistermaat JJ, Sartono E, Supali T, Yazdanbakhsh M The effect of three-monthly albendazole treatment on Th2 responses: Differential effects on IgE and IL-5 Parasite Immunology, 39, 2017
View abstract

Reiding KR, Ruhaak LR, Uh HW, El Bouhaddani S, Van Den Akker EB, Plomp R, McDonnell LA, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, Wuhrer M Human plasma N-glycosylation as analyzed by matrix-assisted laser desorption/ionization-fourier transform ion cyclotron resonance-MS associates with markers of inflammation and metabolic health Molecular and Cellular Proteomics, 16, 228-242, 2017
View abstract

Djuardi Y, Supali T, Wibowo H, Heijmans BT, Deelen J, Slagboom EP, Houwing-Duistermaat JJ, Sartono E, Yazdanbakhsh M Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms Genes and Immunity, 17, 380-385, 2016
View abstract

Wammes LJ, Hamid F, Wiria AE, May L, Kaisar MMM, Prasetyani-Gieseler MA, Djuardi Y, Wibowo H, Kruize YCM, Verweij JJ, De Jon SE, Tsonaka R, Houwing-Duistermaat JJ, Sartono E, Luty AJF, Supali T, Yazdanbakhsh M Community deworming alleviates geohelminth-induced immune hyporesponsiveness Proceedings of the National Academy of Sciences of the United States of America, 113, 12526-12531, 2016
View abstract

Beekman M, Uh HW, van Heemst D, Wuhrer M, Ruhaak LR, Gonzalez-Covarrubias V, Hankemeier T, Houwing-Duistermaat JJ, Slagboom PE Classification for longevity potential: The use of novel biomarkers Frontiers in Public Health, 4, 2016
View abstract

Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, Berndt SI, Bidlingmaier M, Broer L, Cappola A, Ceda GP, Chanock S, Chen MH, Chen TC, Chen YDI, Chung J, Del Greco Miglianico F, Eriksson J, Ferrucci L, Friedrich N, Gnewuch C, Goodarzi MO, Grarup N, Guo T, Hammer E, Hayes RB, Hicks AA, Hofman A, Houwing-Duistermaat JJ, Hu F, Hunter DJ, Husemoen LL, Isaacs A, Jacobs KB, Janssen JAMJL, Jansson JO, Jehmlich N, Johnson S, Juul A, Karlsson M, Kilpelainen TO, Kovacs P, Kraft P, Li C, Linneberg A, Liu Y, Loos RJF, Lorentzon M, Lu Y, Maggio M, Magi R, Meigs J, Mellström D, Nauck M, Newman AB, Pollak MN, Pramstaller PP, Prokopenko I, Psaty BM, Reincke M, Rimm EB, Rotter JI, Saint Pierre A, Schurmann C, Seshadri S, Sjögren K, Slagboom PE, Strickler HD, Stumvoll M, Suh Y, Sun Q, Zhang C, Svensson J, Tanaka T, Tare A, Tönjes A Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits Aging Cell, 15, 811-824, 2016
View abstract

Ghorbanoghli Z, Nieuwenhuis MH, Houwing-Duistermaat JJ, Jagmohan-Changur S, Hes FJ, Tops CM, Wagner A, Aalfs CM, Verhoef S, Gómez García EB, Sijmons RH, Menko FH, Letteboer TG, Hoogerbrugge N, van Wezel T, Vasen HFA, Wijnen JT Colorectal cancer risk variants at 8q23.3 and 11q23.1 are associated with disease phenotype in APC mutation carriers Familial Cancer, 15, 563-570, 2016
View abstract

Finken MJJ, Schrevel M, Houwing-Duistermaat JJ, Kharagjitsingh AV, Dekker FW, Koeleman BP, Roep BO, Wit JM Vitamin D receptor polymorphisms and growth until adulthood after very premature birth Journal of Bone and Mineral Metabolism, 34, 564-570, 2016
View abstract

Rodríguez-Girondo M, Deelen J, Slagboom EP, Houwing-Duistermaat JJ Survival analysis with delayed entry in selected families with application to human longevity. Statistical methods in medical research, 2016
View abstract

Liu F, Hamer MA, Deelen J, Lall JS, Jacobs L, Van Heemst D, Murray PG, Wollstein A, De Craen AJM, Uh HW, Zeng C, Hofman A, Uitterlinden AG, Houwing-Duistermaat JJ, Pardo LM, Beekman M, Slagboom PE, Nijsten T, Kayser M, Gunn DA The MC1R Gene and Youthful Looks Current Biology, 26, 1213-1220, 2016
View abstract

Van Den Akker EB, Pitts SJ, Deelen J, Moed MH, Potluri S, Van Rooij J, Suchiman HED, Lakenberg N, De Dijcker WJ, Uitterlinden AG, Kraaij R, Hofman A, De Craen AJM, Houwing-Duistermaat JJ, Van Ommen GJB, Cox DR, Van Meurs JBJ, Beekman M, Reinders MJT, Slagboom PE To the editor: Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2 Blood, 127, 1512-1515, 2016

Bouhaddani SE, Houwing-Duistermaat J, Salo P, Perola M, Jongbloed G, Uh HW Evaluation of O2PLS in Omics data integration BMC Bioinformatics, 17, 2016
View abstract

van de Rest O, Schutte BAM, Deelen J, Stassen SAM, van den Akker EB, van Heemst D, Dibbets-Schneider P, van Dipten-van der Veen RA, Kelderman M, Hankemeier T, Mooijaart SP, van der Grond J, Houwing-Duistermaat JJ, Beekman M, Feskens EJM, Slagboom PE Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study Aging, 8, 111-126, 2016
View abstract

Reinards THCM, Albers HM, Brinkman DMC, Kamphuis SSM, Van Rossum MAJ, Girschick HJ, Wouters C, Hoppenreijs EPAH, Saurenmann RK, Hinks A, Ellis JA, Bakker E, Verduijn W, Slagboom P, Huizinga TWJ, Toes REM, Houwing-Duistermaat JJ, Ten Cate R, Schilham MW CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis Annals of the Rheumatic Diseases, 74, 2193-2198, 2015
View abstract

Tsonaka R, van der Woude D, Houwing-Duistermaat J Marginal genetic effects estimation in family and twin studies using random-effects models Biometrics, 71, 1130-1138, 2015
View abstract

Uh HW, Beekman M, Meulenbelt I, Houwing-Duistermaat JJ Genotype-Based Score Test for Association Testing in Families Statistics in Biosciences, 7, 394-416, 2015
View abstract

Potjer TP, Van Der Stoep N, Houwing-Duistermaat JJ, Konings ICAW, Aalfs CM, Van Den Akker PC, Ausems MG, Dommering CJ, Van Der Kolk LE, Maiburg MC, Spruijt L, Wagner A, Vasen HFA, Hes FJ Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; A case-control study Medical Genetics BMC Research Notes, 8, 2015
View abstract

Potjer TP, Van Der Stoep N, Houwing-Duistermaat JJ, Konings ICAW, Aalfs CM, Van Den Akker PC, Ausems MG, Dommering CJ, Van Der Kolk LE, Maiburg MC, Spruijt L, Wagner A, Vasen HFA, Hes FJ Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; A case-control study Medical Genetics BMC Research Notes, 8, 2015
View abstract

Punt S, Houwing-Duistermaat JJ, Schulkens IA, Thijssen VL, Osse EM, de Kroon CD, Griffioen AW, Fleuren GJ, Gorter A, Jordanova ES Correlations between immune response and vascularization qRT-PCR gene expression clusters in squamous cervical cancer Molecular Cancer, 14, 2015
View abstract

Tahapary DL, de Ruiter K, Martin I, van Lieshout L, Guigas B, Soewondo P, Djuardi Y, Wiria AE, Mayboroda OA, Houwing-Duistermaat JJ, Tasman H, Sartono E, Yazdanbakhsh M, Smit JWA, Supali T Helminth infections and type 2 diabetes: A cluster-randomized placebo controlled SUGARSPIN trial in Nangapanda, Flores, Indonesia BMC Infectious Diseases, 15, 2015
View abstract

Surakka I, Horikoshi M, Mägi R, Sarin AP, Mahajan A, Lagou V, Marullo L, Ferreira T, Miraglio B, Timonen S, Kettunen J, Pirinen M, Karjalainen J, Thorleifsson G, Hägg S, Hottenga JJ, Isaacs A, Ladenvall C, Beekman M, Esko T, Ried JS, Nelson CP, Willenborg C, Gustafsson S, Westra HJ, Blades M, De Craen AJM, De Geus EJ, Deelen J, Grallert H, Hamsten A, Havulinna AS, Hengstenberg C, Houwing-Duistermaat JJ, Hyppönen E, Karssen LC, Lehtimäki T, Lyssenko V, Magnusson PKE, Mihailov E, Müller-Nurasyid M, Mpindi JP, Pedersen NL, Penninx BWJH, Perola M, Pers TH, Peters A, Rung J, Smit JH, Steinthorsdottir V, Tobin MD, Tsernikova N, Van Leeuwen EM, Viikari JS, Willems SM, Willemsen G, Schunkert H, Erdmann J, Samani NJ, Kaprio J The impact of low-frequency and rare variants on lipid levels Nature Genetics, 47, 589-597, 2015
View abstract

Spagnoli A, Houwing-Duistermaat JJ, Alfó M Mixed-effect models for longitudinal responses with different types of dropout: an application to the Leiden 85-plus study Journal of Applied Statistics, 42, 1896-1910, 2015
View abstract

Weller CM, Wilbrink LA, Houwing-Duistermaat JJ, Koelewijn SC, Vijfhuizen LS, Haan J, Ferrari MD, Terwindt GM, Van Den Maagdenberg AMJM, De Vries B Cluster headache and the hypocretin receptor 2 reconsidered: A genetic association study and meta-analysis Cephalalgia, 35, 741-747, 2015
View abstract

De Rooy DPC, Tsonaka R, Andersson MLE, Forslind K, Zhernakova A, Frank-Bertoncelj M, De Kovel CGF, Koeleman BPC, Van Der Heijde DMFM, Huizinga TWJ, Toes REM, Houwing-Duistermaat JJ, Ospelt C, Svensson B, Van Der Helm-Van Mil AHM Genetic factors for the severity of ACPA-negative rheumatoid arthritis in 2 cohorts of early disease: A genome-wide study Journal of Rheumatology, 42, 1383-1391, 2015
View abstract

Horikoshi M, Mӓgi R, van de Bunt M, Surakka I, Sarin AP, Mahajan A, Marullo L, Thorleifsson G, Hӓgg S, Hottenga JJ, Ladenvall C, Ried JS, Winkler TW, Willems SM, Pervjakova N, Esko T, Beekman M, Nelson CP, Willenborg C, Wiltshire S, Ferreira T, Fernandez J, Gaulton KJ, Steinthorsdottir V, Hamsten A, Magnusson PKE, Willemsen G, Milaneschi Y, Robertson NR, Groves CJ, Bennett AJ, Lehtimӓki T, Viikari JS, Rung J, Lyssenko V, Perola M, Heid IM, Herder C, Grallert H, Müller-Nurasyid M, Roden M, Hypponen E, Isaacs A, van Leeuwen EM, Karssen LC, Mihailov E, Houwing-Duistermaat JJ, de Craen AJM, Deelen J, Havulinna AS, Blades M, Hengstenberg C, Erdmann J, Schunkert H, Kaprio J, Tobin MD, Samani NJ, Lind L, Salomaa V, Lindgren CM, Slagboom PE, Metspalu A, van Duijn CM, Eriksson JG Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation PLoS Genetics, 11, 2015
View abstract

Den Hollander W, Ramos YFM, Bomer N, Elzinga S, Van Der Breggen R, Lakenberg N, De Dijcker WJ, Suchiman HED, Duijnisveld BJ, Houwing-Duistermaat JJ, Slagboom PE, Bos SD, Nelissen RGHH, Meulenbelt I Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage Arthritis and Rheumatology, 67, 2108-2116, 2015
View abstract

'T Hart LM, Fritsche A, Nijpels G, Van Leeuwen N, Donnelly LA, Dekker JM, Alssema M, Fadista J, Carlotti F, Gjesing AP, Palmer CN, Van Haeften TW, Herzberg-Schäfer SA, Simonis-Bik AM, Houwing-Duistermaat JJ, Helmer Q, Deelen J, Guigas B, Hansen T, MacHicao F, Willemsen G, Heine RJ, Kramer MH, Holst JJ, De Koning EJ, Häring HU, Pedersen O, Groop L, De Geus EJ, Slagboom PE, Boomsma DI, Eekhoff EM, Pearson ER, Diamant M In vivo efficacy of HD0471953: A novel GPR119 agonist for the treatment of type 2 diabetes mellitus Diabetes Technology and Therapeutics, 17, S131-S133, 2015

Liu R, Kwok WY, Vliet Vlieland TP, Kroon HM, Meulenbelt I, Houwing-Duistermaat JJ, Rosendaal FR, Huizinga TWJ, Kloppenburg M Mortality in osteoarthritis patients Scandinavian Journal of Rheumatology, 44, 70-73, 2015
View abstract

van der Spoel E, Rozing MP, Houwing-Duistermaat JJ, Eline Slagboom P, Beekman M, de Craen AJM, Westendorp RGJ, van Heemst D Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study Aging, 7, 956-963, 2015
View abstract